This Homemade Chicken Tetrazzini is full of noodles, cream and all kinds of comfort flavors. I know your family will enjoy this casserole dish for a delicious weeknight dinner.

Homemade Chicken Tetrazzini

Who doesn’t love a quick and easy weeknight meal that is full of delicious flavor? When you want comfort food, this dish will really hit the spot. It’s full of chicken, cream sauce, noodles, cheese and allll the good things.

Plus, it only takes a few minutes of prep to get this casserole in the oven and you can be on your way to making sides and desserts for a beautiful family dinner.

Want to make it a meal? Here are my favorite suggestions:

How to Make Homemade Chicken Tetrazzini:

Preheat oven to 350 degrees.

Spray a 9×13 baking dish with nonstick cooking spray and set aside.

In a large bowl, whisk together the cream of chicken soup, cream of mushroom soup, evaporated milk, sour cream, salt, pepper, and garlic powder.

Stir in the chicken breast and one cup of mozzarella cheese.

Add the cooked spaghetti noodles and stir to coat.

Pour the mixture in the prepared baking dish and top with remaining mozzarella cheese and grated Parmesan cheese.

Cover and bake in the preheated oven for 35 minutes. Then, remove the cover and bake for 10 more minutes, until cheese is melted and sauce is bubbling.

Optional: Garnish with dried parsley before serving.

Want more quick and easy dinner recipes? Here are a few of my favorites:

4-Ingredient Chili Mac and Cheese
5-Ingredient Sloppy Joes
Instant Pot Spanish Beef with Rice
Slow Cooker Sausage and Potato Casserole

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Print Recipe

Homemade Chicken Tetrazzini

A quick and easy casserole with noodles and chicken covered in cream sauce.

Prep Time15

Cook Time45

Total Time1

Course: Main Course

Cuisine: Italian

Keyword: Homemade Chicken Tetrazzini

Servings:

Calories: 766kcal

Ingredients

16 ounce package spaghetti prepared
10.75 ounce can cream of chicken soup
10.75 ounce can cream of mushroom soup
12 ounce can evaporated milk
1 cup sour cream
½ teaspoon salt
½ teaspoon pepper
½ teaspoon garlic powder
1 10- ounce can chicken breast or 2 cups shredded cooked chicken
2 cups shredded mozzarella cheese divided
¼ cup grated parmesan cheese
1 teaspoon dried parsley optional

Instructions

Preheat oven to 350 degrees.
Spray a 9x13 baking dish with nonstick cooking spray and set aside.
In a large bowl, whisk together the cream of chicken soup, cream of mushroom soup, evaporated milk, sour cream, salt, pepper, and garlic powder.
Stir in the chicken breast and one cup of mozzarella cheese.
Add the cooked spaghetti noodles and stir to coat.
Pour the mixture in the prepared baking dish and top with remaining mozzarella cheese and grated Parmesan cheese.
Cover and bake in the preheated oven for 35 minutes. Then, remove the cover and bake for 10 more minutes, until cheese is melted and sauce is bubbling.
Optional: Garnish with dried parsley before serving.